The Saints begin their 2025 campaign at the Caesars Superdome against the Cardinals.
This NFC matchup features two teams looking to get back on track after underwhelming 2025 campaigns.
Here's everything you need to know ahead of Cardinals vs Saints.
Spencer Rattler will lead New Orleans' offense out in Week 1 after winning the Saints' quarterback battle against rookie Tyler Shough .
The sophomore will look early and often to star wide receiver Chris Olave and dangerous running back Alvin Kamara in a bid to give the Saints a winning start to the season.
Cardinals' dual-threat quarterback Kyler Murray will lead a potentially dynamic Arizona offense, featuring stars such as sophomore wideout Marvin Harrison, bruising running back James Conner, and Trey McBride, one of the league's best young tight ends.
The winner will take the lead in the all-time head-to-head record, which currently stands at 16-16.
The game will take place at the Caesars Superdome, New Orleans.
Rattler has some bright moments which lift the home crowd, and Kamara finds room at the second level against the new-look Cardinals' linebacker group, but the offense struggles to keep up with the firepower of the Cardinals.
The trio of Murray, Harrison, and McBride proves too much for the Saints' secondary to handle, and Arizona runs up the score.
Cardinals 34 - 17 Saints

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