With the road to Istanbul laid out, all 16 teams know their route if they're to make the final on May 30.
For the first time, there will be six English sides in the Round of 16, after Newcastle defeated Qarabag in the playoff round to book their spot in the next round.
The first legs will be played on 10 and 11 March, with the second legs to take place on 17 and 18 March.
DAZN news takes a look at the Champions League history between the English sides and their round of 16 opponents, as well as the confidence in them progressing to the Quarter-finals.
PSG vs ChelseaThe last time these two sides met was in the final of the Club World Cup over the summer, which Chelsea ran out 3-0 winners.
Looking at their previous Champions League meetings, they haven't met in the competition for 10 years, after facing each other three years in a row in the knockout stages between 2014 and 2016.
When it comes to the fixtures surrounding the tie, Chelsea will face Wrexham in the FA Cup before the first leg in Paris, before hosting Newcastle three days before the return fixture.
Whereas PSG hosts Monaco on the Friday before the first leg, they currently play Nantes on the Sunday before travelling to Stamford Bridge.
Regarding who progresses to the next round, Chelsea will have the edge over the two legs due to the recency with which they've beaten their opponents, and having a home second leg plays its role too.
CONFIDENCE: 3/5
Galatasaray vs LiverpoolStu Forster/Getty ImagesDespite being two big European teams in their own countries, Liverpool and Galatasaray have only faced off five times in the Champions League.
With one being earlier in the league phase, which Galatasaray won 1-0 with a Victor Osimhen goal.
Before that meeting in September, the last time these two sides met was in the 06/07 group stage, which they split games, both winning 3-2 at home.
Liverpool will play West Ham and Wolves twice before travelling to Istanbul, so they should go into that game with confidence that they can take a result home to Anfield, eight days later.
CONFIDENCE: 4/5
Real Madrid vs Manchester CityCarl Recine/Getty ImagesThese two sides will be sick of playing each other come March, with this being the fifth season in a row in which Real Madrid and Manchester City have met in the Champions League knockout rounds.
In the four previous years, Los Blancos have won three of the last four ties, or four out of five, including 19/20, with all having some degree of drama throughout the two legs.
Like Liverpool and Galatasaray, these two met in the league phase, which City won at the Bernabeu and proved to be the last game for Xabi Alonso in charge of Real Madrid.
When deciding who comes through this tie, Real Madrid had to work hard for their playoff victory over Benfica, and with Manchester City winning seven of their last eight, they seem to be getting stronger as the season goes on.
I expect them to go through, but as these fixtures always are, there's usually fireworks.
CONFIDENCE: 3/5
Bayer Leverkusen vs ArsenalRob Newell - CameraSport via Getty ImagesTop seeds Arsenal get rewarded for a dominant and unbeaten league phase with a tie against Bayer Leverkusen.
The German side got a 2-0 aggregate win over Olympiacos in the playoffs, but will be sure to expect a sterner test against a greater opposition.
These two have only met twice in Champions League history, coming in the 01/02 group stage.
Historically, Arsenal haven't fared well against German opposition; in their 28 fixtures, they've only won 11 of them, with the last coming against Borussia Dortmund in November 2014.
Many would expect Arsenal to make it through to the quarter finals, or even further, with ease, considering their squad and the opposition they're set to face. Leverkusen might put up a fight at home, but come the second leg at the Emirates, you'd think that Arsenal would have too much for them.
CONFIDENCE: 5/5
Atletico Madrid vs Tottenham HotspurCharlotte Wilson/Offside/Offside via Getty ImagesThe Champions League has been a welcome distraction to Tottenham, after a disastrous season thus far in the Premier League, and looking like a different team in Europe.
Like their North London rivals, Spurs have barely faced their opponents in Europe, with the only meeting coming more than 60 years ago, so it's a game that doesn't happen very often.
Against Spanish sides, it doesn't read well as they've only managed one win against Spanish teams in the Champions League, with that coming against Real Madrid in the 17/18 season.
Atletico Madrid overpowered Club Brugge in the second leg of their tie, and even if Tottenham's league form isn't something to be proud of or wanted.
They seem to be a different beast in Europe this season, and if performing at that level, they could beat most left in the competition. This tie could be a toss-up, but give the slight edge to the Spaniards to progress.
CONFIDENCE: 2/5
Newcastle vs BarcelonaSerena Taylor/Newcastle United via Getty ImagesNewcastle made it a clean sweep of English sides in the next stage with a 9-2 aggregate win over Qarabag, but now come up against a Barcelona side whose last trip to England didn't end well, being well beaten by Chelsea in November.
The Magpies should know what to expect from the Catalonians after facing them in Matchday one at St. James' Park, and looked the better team aside from two thunderstrikes from Marcus Rashford.
Before meeting them at the start of this season, these two hadn't met in Europe since the 01/02 group stage, in which Barcelona won both meetings 2-0 and 3-1, respectively.
Whether Newcastle progresses to the Quarter-finals or not could depend on the availability of Bruno Guimaraes. If he's fit, then they have a better chance of going through.
If not, then I'd expect Barcelona to have too much across the two legs, but we could see a high-scoring tie between two attacking teams.
CONFIDENCE: 2/5
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