A delightful early goal from former Liverpool player Danny Ings gave Southampton a big 1-0 win over the defending Premier League champions at St Mary's.
James Ward-Prowse's excellent free-kick delivery stumped a makeshift Reds back-line and gave Ings the opportunity to beat Alisson in the Liverpool goal with a delightful lob with less than two minutes on the clock.
For much of the game, it was the hosts who looked mostly likely to score the game's second and double their lead as Jurgen Klopp's often-free-scoring side failed to muster a shot on target for over three-quarters of the contest.
Sadio Mane, who signed for the 2019-20 league winners from Southampton, was instrumental in many of the visitors' best hopes of getting back into the game but could not find the shot or assist to beat Fraser Forster, back in the side following Alex McCarthy's positive COVID-19 result.
At the full-time whistle, Saints manager Ralph Hasenhüttl could not hide his emotions on the touchline after securing one of the biggest results of his managerial career.
Liverpool remain top of the table on goal difference, but can be overtaken by rivals Manchester United if they avoid defeat in their game in hand. Southampton, meanwhile, move back up to sixth albeit having played a game more than many of their competition for a European place.
You can re-live the major happenings of the match below.